![]() Researchers are trying to use this interaction for a clinical advantage by investigating whether some expensive medications could be taken in lower amounts but still retain the same therapeutic effects if taken with grapefruit juice. If you are concerned that you may be taking a medication that is affected by grapefruit juice, talk to your doctor. This means that if you drink grapefruit juice, it may affect how these medications are processed by your body, potentially increasing the medication levels. zolpidem), and other centrally-acting medications, are processed by this enzyme. Many types of psychiatric medications, including most SSRIs, SNRIs, benzodiazepines, sedatives (e.g. This can be dangerous if a patient is not aware of this effect, as increased medication concentration can lead to adverse reactions. its recovery half-life is one day), taking medications at a different time of day is not an adequate solution to avoid this problem. Because it takes grapefruit juice approximately one day to leave the body (i.e. This interaction may result in higher levels of some drugs in the body. Grapefruit juice has been demonstrated to inhibit the functioning of CYP3A4 and its effect on the metabolism of a number of drugs by varying degrees. It is important in many drug-drug and drug-food interactions, and it is one of the first enzymes to break down medications when they enter the body. CYP3A4 is an intestinal enzyme that is part of the Cytochrome P450 metabolic system.
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